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Pneumonia
Pneumonia symptoms vary greatly, depending on any underlying conditions
a person may have and the type of organism causing the infection:
Bacterial Agents in Pneumonia
Pneumonia in adults is most commonly caused by bacterial
agents. It is a frequent respiratory infection in industrialized
cities, lower socioeconomic groups or in cases of crowded living
quarters. The incidence of bacterial pneumonia increases in winter
and spring
in temperate zones. Most infectious pneumonia is caused by bacteria
and 60-80% of all bacterial pneumonia is caused by Streptococcus
pneumoniae.
These organisms are routinely found in the upper respiratory tract
of healthy persons. It is when they are drawn into the lower respiratory
tract of susceptible individuals that they cause infection. Pneumococci
are spread by droplets or direct contact with an infected person.
Bacterial pneumonia has an incubation period of 1-3 days. Antibiotic
therapy
with penicillin or erythromycin makes the patient non-infective
and generally results in a rapid recovery.
One may develop bacterial pneumonia symptoms after having an upper respiratory infection such as a cold or the flu. Signs and symptoms of pneumonia, which are likely to come on suddenly, include shaking, chills, a high fever, sweating, chest pain (pleurisy), and a cough that produces thick, rust-colored, greenish or yellow phlegm. Older adults or patients of chronic illness may have fewer or milder symptoms. However, that does not mean pneumonia symptoms should be treated lightly. For people age 65 and older, or those with a chronic illness, pneumonia can be extremely serious. The tissue of part of a lobe of the lung, an entire lobe, or even most of the lung''''s five lobes becomes completely filled with liquid (this is called "consolidation"). The infection quickly spreads through the bloodstream and the whole body is invaded. The streptococcus pneumoniae is the most common cause of bacterial pneumonia. It is one form of pneumonia for which a vaccine is available. Viruses and Pneumonia
Viruses, including the same viruses that cause influenza, are responsible for half of all cases of pneumonia.
Pathogens include
the Respiratory syncytial virus (RSV), parainfluenza, adenovirus,
influenza, enterovirus, and rhinovirus. Viral pneumonia strikes primarily
in the
fall and winter and tends to be more serious in people with cardiovascular
or lung disease. It usually starts with a dry cough, headache,
fever, muscle pain, and fatigue. As the pneumonia progresses, a patient
may become breathless and develop a cough that produces phlegm. With
viral
pneumonia, risks of developing a secondary bacterial pneumonia
increase
as well. Infection with the influenza virus may be severe and occasionally
fatal. If the influenza virus destroys alveolar epithelial cells,
plasma leaks from the capillary, filling the airspace. If enough
alveoli are
involved, patients drown in their own plasma. This is especially
true of patients with increased pulmonary capillary pressure, because
destruction
of alveolar epithelial cells will lead to greater extravasation
of plasma and more pulmonary edema than in otherwise healthy people.
If the virus invades the lungs and multiplies, there are almost no
physical
signs of lung tissue becoming filled with fluid. Pneumonia finds
many of its victims among those who have pre-existing heart or lung
disease
or are pregnant. In extreme cases, the patient has a desperate
need
for air and extreme breathlessness. Viral pneumonias may be complicated
by an invasion of bacteria, with all the typical pneumonia symptoms
of bacterial pneumonia.
Mycoplasmas
Because of its somewhat different
pneumonia symptoms and physical signs, and because the course of the
illness differed
from classical pneumococcal pneumonia, mycoplasma pneumonia was once
believed to be caused by one or more undiscovered viruses and was called "primary
atypical pneumonia." Identified during World War II, mycoplasmas
are the smallest free-living agents of disease in humankind, unclassified
as to whether bacteria or viruses, but having characteristics of both.
They generally cause a mild and widespread pneumonia. They affect all
age groups, occurring most frequently in older children and young adults.
The death rate is low, even in untreated cases. These tiny organisms
cause symptoms similar to both bacterial and viral pneumonia, although
the symptoms appear more gradually and are often milder. If a patient
has been diagnosed with walking pneumonia, it is probably caused by
a mycoplasma. One may not be sick enough to stay in bed, and many people
with mycoplasma pneumonia never seek medical care. This type of pneumonia
spreads easily in situations where people congregate and is common
in child care centers and among school children and young adults. Although
not caused by a bacteria, mycoplasma pneumonia responds well to treatment
with antibiotics.
Chlamydia Trachomatis
This is a sexually transmitted disease that may also cause pneumonia and bronchitis. It usually
is a subacute infection of early infancy producing a sudden cough and eosinophilia without
fever that lasts from 1-3 weeks, but it may occur in adults too.
It is transmitted to infants at birth from the cervix of an infected
mother.
Adults having chlamydial pneumonia are usually immunocompromised
with the infection spreading from the eye (conjunctival) to the respiratory
tract via the nasolacrimal duct. Pneumonia Symptoms
Diagnosis is by isolation of the organism and by finding antibodies in the blood. Erythromycin and tetracycline are effective therapies. Eukaryotic Pneumonia
Pneumocystis carinii is an organism of mixed
fungal and protozoal character that causes and acute, often fatal,
respiratory infection in infants or immunocompromised patients.
Pneumonia caused by a parasite, Pneumocystis carinii, is the most common
opportunistic
infection affecting Americans with AIDS. People whose immune systems
are compromised by treatment with steroids, organ transplants or
cancer also are at risk. The signs and symptoms of Pneumocystis carinii
pneumonia
(PCP) include a cough that doesn''''t go away, fever and trouble
breathing. Symptoms are labored or difficult breathing, cyanosis
and heavy infiltrates
in the alveolar spaces. Diagnosis is by finding the organism in
mucous smears or by biopsy of lung tissue. Treatment is by the use
of trimethoprim-sulfanethoxazole
or pentamidine isothionate. When treated, 60-90 % of patients survive.
If untreated it is uniformly fatal.
Pneumonia and Fungi
Certain types of fungus also can cause pneumonia, especially Histoplasma capsulatum, which
is common in the Mississippi and Ohio River valleys. Some people experience no symptoms at all after
inhaling this fungus. Others develop symptoms of acute pneumonia, and
still
others may develop a chronic pneumonia that persists for months.
The symptoms of bacterial pneumonia develop abruptly and may include
chest
pain, fever, shaking, chills, shortness of breath.
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